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Pharmaceutical Pharmacology
 Services

ONLINE | CLASSROOM | CAMPUS TRAINING

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Clintech brings several years of experience of performing all types of analytical solutions. Our technical know-how and extensive experience with analysing and interpretation allow us to develop a range of authenticated results.

Anti Cancer Activity

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  • Cytotoxicity assay by MTT/SRB/Trypan blue

  • Clonogenic assay

  • Apoptosis – Nuclear staining with DAPI

  • Alkylating activity assay

  • TUNEL assay

  • Endonuclease assay

  • DNA fragmentation analysis / DNA ladder assay

  • Cancer specific gene expression analysis (P53, BCl2, Capsase 3, VEGF, cyclin D1, cyclin B1, STAT3 etc.)

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In Vitro Activity

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  • Cytotoxicity assay by MTT/SRB/Trypan blue

  • Clonogenic assay

  • Apoptosis – Nuclear staining with DAPI

  • Alkylating activity assay

  • TUNEL assay

  • Endonuclease assay

  • DNA fragmentation analysis / DNA ladder assay

  • Cancer specific gene expression analysis

  • P53, BCl2, Capsase 3, VEGF, cyclin D1, cyclin B1, STAT3 etc

Anti Diabetes Activity

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In vivo Activity

  • Alloxan induced diabetic rat model

  • Streptozotocin induced diabetic rat model

In Vitro Activity

  • Glucose uptake studies in skeletal muscle cell lines (Non-radio labeled assay).

  • Glucose uptake in isolated rat hemi diaphragm

  • Gene expression studies (PPARγ, GLUT-4 etc)

  • Alpha-Amylase inhibitory activity

  • Alpha-galactosidase inhibitory activity

  • Alpha-glucosidase activity

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Hepatoprotective Activity

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In vivo Activity

  • Hepatoprotective study against selected toxicant in rats

In Vitro Activity

  • Hepatoprotective study against selected toxicant.

  • Hepatoprotective study in isolated primary rat hepatocytes.

  • Gene expression studies

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Anti infective Activity

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In vivo Activity

  • Different wound healing models in mice/rats

In Vitro Activity

  • Anti microbial activity by Zone of inhibition.

  • Anti microbial activity by MIC determination

  • Antibiotic sensitivity testing

  • TLC bioautography

  • In vitro anti viral studies

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Other in vivo services

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  • Hypercholesterolemia

  • Arthritis

  • Osteoporosis

  • Benign prostatic Hyperplasia

  • Spermatogenesis

  • Allergy

  • Antitussive

  • Psoriasis

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Other Services

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  • Antimicrobial

  • Anti viral

  • Cytotoxicity

  • Cell proliferation

  • Cancer

  • Diabetes

  • Hepatoprotection

  • Obesity

  • Immunomodulatory

  • Inflammation

  • Skin whitening

  • Skin irritation (Dermal toxicity)

  • Psoriasis

  • Wound healing

  • Genotoxicity

  • Drug permeability

  • Gene expression analysis

  • Enzyme and Immunoassays (ELISA)

Antioxidant Activity

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In vivo Activity

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  • Antioxidant status in rats by hepatic injury model

  • Antioxidant status in tumor bearing mice model

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In Vitro Activity

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  • DPPH scavenging assay

  • Scavenging of Nitric Oxide radical

  • Lipid peroxidation inhibitory activity

  • Evaluation of Total Antioxidant capacity

  • Ferric ion reducing power assay

  • Scavenging of Hydroxyl Radical by p-NDA Method

  • Scavenging of Hydrogen Peroxide

  • Scavenging of ABTS radical cation Assay

  • Total Phenolic and Flavonoid content estimation

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Immunomodulatory & Inflammation Activity

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In vivo Activity

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  • Triton induced hyperlipidemia model in mice/rats

  • Cocktail induced hypercholesterolemia model

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In Vitro Activity

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Anti adepogensis studies in 3T3L-1 pre adepocytes by

  • Oil Red-O staining

  • Cell triglyceride assay

  • Gene expression studies (PPAR-gamma, SREBF etc)

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Toxicology

  • Cytotoxicity

  • Genotoxicity

  • AMES test

  • Chromosomal aberration in CHO-K1 cells

  • Micronucleus assay

  • In vitro organ specific toxicity

  • Skin irritation studies (as OECD)

  • In vivo toxicity studies

  • Acute

  • Sub acute

  • Chronic

  • Specific organ toxicity

  • Reproductive toxicity

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Anti Obesity Activity

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  • Anti adepogensis studies in 3T3L-1 pre adepocytes by

  • Oil Red-O staining

  • Cell triglyceride assay

  • Gene expression studies (PPAR-gamma, SREBF etc)

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Microbiology

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  • Microbial Analysis (TMC & TFC)

  • Most Probable Number (MPN)

  • Specific pathogen detection

  • Preservative efficacy testing (PET)

  • Sterility testing

  • Bacterial Endotoxin Test (BET)

  • Water analysis

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Others

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  • Glucose oxidase & Lactoperoxidase determination

  • Analysis of products for Gliadin, Aflatoxins, mycotoxins etc

  • Marker analysis of herbal products

  • Disintegration studies for formulations

  • Dissolution studies for formulations

  • Pyrogen testing

  • In vitro skin irritation studies for cosmetics

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